نسخه تجريبية

EVA Pharma

Triclazole

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Triclabendazole differs from other benzimidazoles in that is a narrow

Properties:

spectrum anthelmintic. The drug accumulates significantly in both immature and adult stages of Fasciola hepatica and stimulates the major routes of the parasite's energy generating system. As demonstrated by glucose derived acetate and propionate formation. However, under these conditions the parasite's motility decreased, indicating that the drug is not associated with inhibition of the energy generating pathways. Triclabendazole inhibits colchicine binding to microtubular proteins suggesting interference of the drug with microtubular structure and function. The drug strongly inhibits the release of proteolytic enzymes in immature and adult Parasites, a process dependent on microtubular functions.

The precise molecular mode of action of this faciolicidal drug remains to be elucidated. 75-50 % of the orally administered dose of triclabendazole is absorbed from the gastrointestinal tract. Very rapidly, absorbed triclabendazole is almost completely oxidized to its sulfoxide and sulfone.

In cattle, triclabendazole sulfoxide reaches peak concentrations approximately 27 hours after administration of the product and the sulfone reaches peak concentrations 64 to 72 hours after administration. In sheep, triclabendazole sulfoxide reaches peak concentrations approximately 20 hours after administration of the product and the sulfone reaches peak concentrations 30 to 32 hours after administration. Both metabolites bind strongly to plasma proteins, particularly albumin.

Metabolites are excreted via the bile mainly as conjugates. More than of the total dose of triclabendazole is excreted in the feces. About %2 in the urine and less than %1 in the milk. The eliminations is virtually complete by 10 days after administration.

Indications:

For the treatment of adult, immature and early immature stages of liver fuke (fasciola hepatica) susceptible to triclabendazole.

Company

EVA Pharma

SKU

EVA-006

Type

Large

Country of origin

Egypt

Size

1 L

Medication Type

Liquid

Characterization

drinking

Dosage

12.5 cm /100 kg

Active Component

Triclabendaole 10%

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